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The distribution of these PUFA derivatives in specific membranes and vesicles will require further chemical analysis

Through integrated cell-biological, biochemical, and structural analyses, we demonstrate that this gate-locking activity is both necessary and sufficient for cohesion maintenance, operates independently of Pds5 competition, and is tightly regulated during the cell cycle

The information contained herein should not be used as a substitute for the advice of a qualified physician

Collectively, these data identify TFG as a critical factor upstream of ESCRT-I and thus as having a role early in the ESCRT assembly cascade that enables lysosomal membrane repair

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ROS-induced damage to important biomolecules is widely recognized as a significant mechanism contributing to the development of various chronic diseases (Valko et al., 2005[430])